The Brier Manufacturing Company, the second largest costume jewelry maker in Providence, commissioned this building in 1928 from the architect Frank B. Perry (who would also build the Coro Building on Point Street the following year) and occupied it until the late 1970s. Its brand name “Little Nemo” was inspired by the successful comic strip by Winsor McCay from 1905 to 1926 in the New York Herald. Due to the success of the jewelry, Brier changed its name to the Little Nemo Manufacturing Company. The building is today occupied by Brown University’s Alpert Medical School.